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Transcriptomic analysis of Panc10.05 cells treated with indisulam

ABSTRACT: Transcriptomic analysis of Panc10.05 cells treated with indisulam

PROVIDER: PRJNA823945 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of Panc10.05 cells treated with indisulam

Project description:Indisulam is an abandoned drug that acts as a molecular glue, inducing degradation of splicing factor RBM39 through interaction with CRL4DCAF15. We generated spontaneoulsy indisulam-resistant Panc10.05 cells and studied their response to indisulam.

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Transcriptomic expression of A549 and SUM159 cells treated with palbociclib and indisulam

Project description:Indisulam is a molecular glue targeting a splicing factor RBM39 for degradation. To assess splicing errors when treating the cells with indisulam, palbociclib and the combination we perform RNA sequencing and analyze splicing errors.

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Transcriptomic expression of SUM159 cells treated with palbociclib and indisulam

Project description:Inducing senescence in cancer cells is emerging as a new therapeutic strategy. We tested the senescence induction of palbociclib and indisulam in SUM159 cells, and profiled these for senescence associated gene signatures.

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Transcriptomic expression of A549 cells treated with palbociclib and indisulam or PF-06873600 and SUM159 cells treated with PF-06873600

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Global transcriptional profiling of wild type and LATS1/2 KO CAL27 cells in response to indisulam

Project description:mRNA sequencing of WT and LATS1/2 KO CAL27 cells were treated with indisulam 1 μM for 24hr to profile and characterize dysregulated pathways and alternative splicing in response to indisulam

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Transcriptomic expression of A549 cells treated with palbociclib and indisulam or PF-06873600 and SUM159 cells treated with PF-06873600

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