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RNAseq of macrophages and NK cells from MC38 tumors with PtdSer externalization blockade

ABSTRACT: RNAseq of macrophages and NK cells from MC38 tumors with PtdSer externalization blockade

PROVIDER: PRJNA826485 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18744007_1.fastq.gz	Fastqsanger.gz
	SRR18744007_2.fastq.gz	Fastqsanger.gz
	SRR18744008_1.fastq.gz	Fastqsanger.gz
	SRR18744008_2.fastq.gz	Fastqsanger.gz
	SRR18744009_1.fastq.gz	Fastqsanger.gz

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RNAseq of macrophages and NK cells from MC38 tumors with PtdSer externalization blockade

Project description:The goals of this study are to compare NGS-derived transcriptome profiling (RNA-seq) of tumor associated macrophages from WT MC38 tumors and Tmem30a KO tumors; and NK cells from WT and Xkr8 KO MC38 TILs

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RNAseq of macrophages from MC38 tumors with PtdSer externalization blockade

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Project description:Primary irradiated MC38 tumors and secondary MC38 non-irradiated tumors. Subcutaneous MC38 tumors in C57BL/6 mice Concurrent treatment with anti-PD-L1.

2023-10-15 | E-MTAB-13389 | biostudies-arrayexpress

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Project description:Purpose: Use RNA-seq to characterize the anti-tumor immune response induced by ALPN-202 and compare to that of anti-PD-L1 treatment alone. Methods: mRNA was isolated from MC38/hPD-L1 tumors 72 hours after a single dose of ALPN-202 (n=4), anti-PD-L1 mAb (durvalumab) (n=4), or Fc control (n=4). Results: ALPN-202 treatment resulted in elevated expression of multiple T cell, NK cell, myeloid cell genes. Additionally, there was a strong increase in genes commonly associated with a proinflammatory response including cytokines, chemokines and surface markers. Conclusions: ALPN-202 treatment resulted in a strong anti-tumor immune response that was more potent than that generated by blockade of PD-L1 alone.

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Project description:We show that endothelial cells from MC38 tumors in WT mice express high chemokine Ccl8 than in Apelin knockout mice. We found that Apelin induces Ccl8 expression in ECs and enhances anti-tumor immunity.

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