Giardia intestinalis
Ontology highlight
ABSTRACT:
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Other | ||||
| AACB03.dat.gz | Other | |||
| AACB03.fasta.gz | Fasta.gz | |||
| AACB03.master.dat | Other | |||
| ACGJ01.dat.gz | Other |
Items per page: 5 1 - 5 of 567 |
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This model is described in the article:
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Vanee N, Roberts SB, Fong SS, Manque
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Chem. Biodivers. 2010 May; 7(5):
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The apicomplexan Cryptosporidium is a protozoan parasite of
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This model is hosted on
BioModels Database
and identified by:
MODEL1507180071.
To cite BioModels Database, please use:
BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models.
To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
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Project description:Giardia duodenalis is the protozoan agent responsible for the majority of parasitic gastroenteritis in humans worldwide. Disease pathology includes malabsorption and maldigestion, cell apoptosis and small intestinal barrier dysfunction, which occurs in absence of known toxins, cell invasion and overt inflammation. To understand pathogenesis, host-parasite in vitro interaction models provide global insights into disease induction and virulence. Hence, we performed the first proteomic analysis of G. duodenalis trophozoites interacted with intestinal epithelial cells (IECs, HT-29) for 6 hours, and compared it to trophozoites exposed to cell-free fractions of host-soluble signals. This has allowed us to demonstrate that distinct and independent protein cascades are induced by host attachment compared to host soluble signals. We utilised a tandem mass tag (TMT) approach and evaluated it as quantitative proteomics for the first time in Giardia.
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