Proteomics

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Malignant pleural mesothelioma targeted proteomics signature from blood


ABSTRACT: Targeted proteomics based blood biomarkers for malignant pleural mesothelioma cancer

ORGANISM(S): Homo Sapiens

SUBMITTER: Ferdinando Cerciello  

PROVIDER: PXD018457 | panorama | Mon Aug 03 00:00:00 BST 2020

REPOSITORIES: PanoramaPublic

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Publications

Verification of a Blood-Based Targeted Proteomics Signature for Malignant Pleural Mesothelioma.

Cerciello Ferdinando F   Choi Meena M   Sinicropi-Yao Sara L SL   Lomeo Katie K   Amann Joseph M JM   Felley-Bosco Emanuela E   Stahel Rolf A RA   Robinson Bruce W S BWS   Creaney Jenette J   Pass Harvey I HI   Vitek Olga O   Carbone David P DP  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20200730 10


<h4>Background</h4>We have verified a mass spectrometry (MS)-based targeted proteomics signature for the detection of malignant pleural mesothelioma (MPM) from the blood.<h4>Methods</h4>A seven-peptide biomarker MPM signature by targeted proteomics in serum was identified in a previous independent study. Here, we have verified the predictive accuracy of a reduced version of that signature, now composed of six-peptide biomarkers. We have applied liquid chromatography-selected reaction monitoring  ...[more]

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