Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Young Ah Goo
PROVIDER: PXD028627 | panorama | Sat Sep 24 00:00:00 BST 2022
REPOSITORIES: PanoramaPublic
Melani Rafael D RD Des Soye Benjamin J BJ Kafader Jared O JO Forte Eleonora E Hollas Michael M Blagojevic Voislav V Negrão Fernanda F McGee John P JP Drown Bryon B Lloyd-Jones Cameron C Seckler Henrique S HS Camarillo Jeannie M JM Compton Philip D PD LeDuc Richard D RD Early Bryan B Fellers Ryan T RT Cho Byoung-Kyu BK Mattamana Basil Baby BB Goo Young Ah YA Thomas Paul M PM Ash Michelle K MK Bhimalli Pavan P PP Al-Harthi Lena L Sha Beverly E BE Schneider Jeffrey R JR Kelleher Neil L NL
Journal of proteome research 20211208 1
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy chains. Ig-MS uses recent advances in protein mass spectrometry (MS) for multiparametric readout of antibodies, with new metrics like Ion Titer (IT) and Degree of Clonality (DoC) capturing the heterogeneity and relative abundance of ...[more]