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Proteomic Blueprint of the Pituitary anterior and posterior lobes for better understanding of the physiology of pituitary gland.

ABSTRACT: This study provides a comprehensive proteomic analysis of five matched pairs of the anterior and posterior lobe of the pituitary, which was used to study the proteomic signature specific to both anterior and posterior lobes.

ORGANISM(S): Homo Sapiens

SUBMITTER: Sanjeeva Srivastava

PROVIDER: PXD029991 | panorama | Tue Dec 06 00:00:00 GMT 2022

REPOSITORIES: PanoramaPublic

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The First Pituitary Proteome Landscape From Matched Anterior and Posterior Lobes for a Better Understanding of the Pituitary Gland.

Banerjee Arghya A Biswas Deepatarup D Barpanda Abhilash A Halder Ankit A Sibal Shamira S Kattimani Rohit R Shah Abhidha A Mahadevan Anita A Goel Atul A Srivastava Sanjeeva S

Molecular & cellular proteomics : MCP 20221205 1

To date, very few mass spectrometry (MS)-based proteomics studies are available on the anterior and posterior lobes of the pituitary. In the past, MS-based investigations have focused exclusively on the whole pituitary gland or anterior pituitary lobe. In this study, for the first time, we performed a deep MS-based analysis of five anterior and five posterior matched lobes to build the first lobe-specific pituitary proteome map, which documented 4090 proteins with isoforms, mostly mapped into ch ...[more]

PMID: 36470533

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