Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Annelies Bogaert
PROVIDER: PXD030285 | panorama | Tue Aug 02 00:00:00 BST 2022
REPOSITORIES: PanoramaPublic
Bogaert Annelies A Fijalkowska Daria D Staes An A Van de Steene Tessa T Demol Hans H Gevaert Kris K
Molecular & cellular proteomics : MCP 20220702 8
Ribosome profiling has revealed translation outside canonical coding sequences, including translation of short upstream ORFs, long noncoding RNAs, overlapping ORFs, ORFs in UTRs, or ORFs in alternative reading frames. Studies combining mass spectrometry, ribosome profiling, and CRISPR-based screens showed that hundreds of ORFs derived from noncoding transcripts produce (micro)proteins, whereas other studies failed to find evidence for such types of noncanonical translation products. Here, we att ...[more]