Proteomics

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Effect of burn wound treatment with fish skin on mouse skin proteome


ABSTRACT: This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. Proteomic analysis of the fish skin revealed the presence of antimicrobial peptides. In combination with histological and other data, these results suggest that fish skin can serve as an innovative and cost-effective therapeutic alternative for burn victims to facilitate vascularization and reduce bacterial infection.

ORGANISM(S): Mus Musculus

SUBMITTER: Dietmar Kültz  

PROVIDER: PXD050514 | panorama | Mon Mar 11 00:00:00 GMT 2024

REPOSITORIES: PanoramaPublic

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Publications

Tilapia Fish Skin Treatment of Third-Degree Skin Burns in Murine Model.

Garrity Carissa C   Garcia-Rovetta Christina C   Rivas Iris I   Delatorre Ubaldo U   Wong Alice A   Kültz Dietmar D   Peyton Jamie J   Arzi Boaz B   Vapniarsky Natalia N  

Journal of functional biomaterials 20231011 10


This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. Despite the promises of this therapy, there are few studies explaining the healing mechanisms behind the application of tilapia fish skin. In this study, mice with third-degree burns were treat  ...[more]

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