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Hs_Albuminome_CSF

ABSTRACT: Albuminome from human CSF

REANALYSIS of: PXD000036

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Others

SUBMITTER: Holewinski RJ, Jin Z, Powell MJ, Maust MD, Van Eyk JE

PROVIDER: PAe005108 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Publications

A fast and reproducible method for albumin isolation and depletion from serum and cerebrospinal fluid.

Holewinski Ronald J RJ Jin Zhicheng Z Powell Matthew J MJ Maust Matthew D MD Van Eyk Jennifer E JE

Proteomics 20130129 5

Analysis of serum and plasma proteomes is a common approach for biomarker discovery, and the removal of high-abundant proteins, such as albumin and immunoglobins, is usually the first step in the analysis. However, albumin binds peptides and proteins, which raises concerns as to how the removal of albumin could impact the outcome of the biomarker study while ignoring the possibility that this could be a biomarker subproteome itself. The first goal of this study was to test a new commercially ava ...[more]

PMID: 23300121

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