Hs_SubstantiaNigra_TMT6plex
Ontology highlight
ABSTRACT:
REANALYSIS of: PXD000427
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: Licker V, et al.
PROVIDER: PAe005156 | PeptideAtlas | 2014-12-31
REPOSITORIES: PeptideAtlas
Publications
Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis.
Licker Virginie V Turck Natacha N Kövari Enikö E Burkhardt Karim K Côte Mélanie M Surini-Demiri Maria M Lobrinus Johannes A JA Sanchez Jean-Charles JC Burkhard Pierre R PR
Proteomics 20140218 6
Parkinson's disease (PD) pathology spreads throughout the brain following a region-specific process predominantly affecting the substantia nigra (SN) pars compacta. SN exhibits a progressive loss of dopaminergic neurons responsible for the major cardinal motor symptoms, along with the occurrence of Lewy bodies in the surviving neurons. To gain new insights into the underlying pathogenic mechanisms in PD, we studied postmortem nigral tissues dissected from pathologically confirmed PD cases (n = 5 ...[more]
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