Dataset Information

Hs_NSCLC_Phospho

ABSTRACT: This is a large-scale survey of tyrosine kinase activity in lung cancer. Tyrosine kinase signaling across 41 non-small cell lung cancer (NSCLC) cell lines and over 150 NSCLC tumors are characterized Using a phosphoproteomic approach.

OTHER RELATED OMICS DATASETS IN: PRJNA31257PRJNA176729

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Others

SUBMITTER: Steven P Gygi

PROVIDER: PAe005321 | PeptideAtlas | 2007-12-31

REPOSITORIES: PeptideAtlas

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Publications

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

Rikova Klarisa K Guo Ailan A Zeng Qingfu Q Possemato Anthony A Yu Jian J Haack Herbert H Nardone Julie J Lee Kimberly K Reeves Cynthia C Li Yu Y Hu Yerong Y Tan Zhiping Z Stokes Matthew M Sullivan Laura L Mitchell Jeffrey J Wetzel Randy R Macneill Joan J Ren Jian Min JM Yuan Jin J Bakalarski Corey E CE Villen Judit J Kornhauser Jon M JM Smith Bradley B Li Daiqiang D Zhou Xinmin X Gygi Steven P SP Gu Ting-Lei TL Polakiewicz Roberto D RD Rush John J Comb Michael J MJ

Cell 20071201 6

Despite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our ability to identify drug targets and predict response. Here we present the first large-scale survey of tyrosine kinase activity in lung cancer. Using a phosphoproteomic approach, we characterize tyrosine kinase signaling across 41 non-small cell lung cancer (NSCLC) cell lines and over 150 NSCLC tumors. Profiles of phosphotyrosine signaling a ...[more]

PMID: 18083107

Dataset Information

Hs_NSCLC_Phospho

Publications

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

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