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AgTotal

ABSTRACT: Isolation of Aggregates from Worm Lysates

REANALYSIS of: PXD001364

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Caenorhabditis Elegans (c. Elegans)

SUBMITTER:

PROVIDER: PAe005582 | PeptideAtlas | 2015-12-31

REPOSITORIES: PeptideAtlas

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Publications

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther Dirk M DM Kasturi Prasad P Zheng Min M Pinkert Stefan S Vecchi Giulia G Ciryam Prajwal P Morimoto Richard I RI Dobson Christopher M CM Vendruscolo Michele M Mann Matthias M Hartl F Ulrich FU

Cell 20150501 4

Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during aging, resulting in a severe proteome imbalance. These changes are reduced in the long-lived daf-2 mutant but are enhanced in the short-lived daf-16 mutant. While ribosomal proteins de ...[more]

PMID: 25957690

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