ER-stress-induced_transcription
Ontology highlight
ABSTRACT:
REANALYSIS of: PXD000636
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Caenorhabditis Elegans (c. Elegans)
SUBMITTER:
PROVIDER: PAe005594 | PeptideAtlas | 2015-12-31
REPOSITORIES: PeptideAtlas
Publications
Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.
Marza Esther E Taouji Saïd S Barroso Kim K Raymond Anne-Aurélie AA Guignard Léo L Bonneu Marc M Pallares-Lupon Néstor N Dupuy Jean-William JW Fernandez-Zapico Martin E ME Rosenbaum Jean J Palladino Francesca F Dupuy Denis D Chevet Eric E
EMBO reports 20150204 3
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the Unfolded Protein Response (UPR(ER)) to restore ER homeostasis. The AAA(+) ATPase p97/CDC-48 plays key roles in ER stress by promoting both ER protein degradation and transcription of UPR(ER) genes. Although the mechanisms associated with protein degradation are now well established, the molecular events involved in the regulation of gene transcription by p97/CDC-48 remain unclear. Using a reporter-based genome ...[more]
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