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MRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: A population-based simulation study


ABSTRACT: mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: A population-based simulation study. This is an example of a model that uses parameter uncertainty, which is specified in terms of probability density functions.

SUBMITTER: David Nickerson  

PROVIDER: Walmsley_Rodriguez_2013 | Physiome Model Repository |

REPOSITORIES: PMR

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mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study.

Walmsley John J   Rodriguez Jose F JF   Mirams Gary R GR   Burrage Kevin K   Efimov Igor R IR   Rodriguez Blanca B  

PloS one 20130220 2


Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in human heart failure and atrial fibrillation, such as action potential (AP) prolongation, increased AP triangulation, decreased intracellular calcium transient (CaT) magnitude and decreased CaT triangulation. Our goal is to investigate whether the inform  ...[more]

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