Proctor, 2007
Ontology highlight
ABSTRACT:
SUBMITTER: 
David Nickerson
PROVIDER: proctor_2007 | Physiome Model Repository |
REPOSITORIES: PMR
Publications
An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline.
Proctor Carole J CJ Tsirigotis Maria M Gray Douglas A DA
BMC systems biology 20070321
<h4>Background</h4>The ubiquitin-proteasome system is responsible for homeostatic degradation of intact protein substrates as well as the elimination of damaged or misfolded proteins that might otherwise aggregate. During ageing there is a decline in proteasome activity and an increase in aggregated proteins. Many neurodegenerative diseases are characterised by the presence of distinctive ubiquitin-positive inclusion bodies in affected regions of the brain. These inclusions consist of insoluble, ...[more]
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