Proteomics,Multiomics

Dataset Information

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Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts


ABSTRACT: Egg secretions fractionated by 2D electrophoresis and analysed by electrospray MS/MS

OTHER RELATED OMICS DATASETS IN: PRJNA128885

INSTRUMENT(S): instrument model, QSTAR Pulsar, Q-Tof ultima, 4700 Proteomics Analyzer

ORGANISM(S): Schistosoma Mansoni (blood Fluke)

SUBMITTER: R Alan Wilson  

PROVIDER: PRD000251 | Pride | 2010-06-03

REPOSITORIES: Pride

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Publications

Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts.

DeMarco Ricardo R   Mathieson William W   Manuel Sophia J SJ   Dillon Gary P GP   Curwen Rachel S RS   Ashton Peter D PD   Ivens Alasdair C AC   Berriman Matthew M   Verjovski-Almeida Sergio S   Wilson R Alan RA  

Genome research 20100706 8


Schistosoma mansoni is a well-adapted blood-dwelling parasitic helminth, persisting for decades in its human host despite being continually exposed to potential immune attack. Here, we describe in detail micro-exon genes (MEG) in S. mansoni, some present in multiple copies, which represent a novel molecular system for creating protein variation through the alternate splicing of short (< or =36 bp) symmetric exons organized in tandem. Analysis of three closely related copies of one MEG family all  ...[more]

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