Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA128885
INSTRUMENT(S): instrument model, QSTAR Pulsar, Q-Tof ultima, 4700 Proteomics Analyzer
ORGANISM(S): Schistosoma Mansoni (blood Fluke)
SUBMITTER: 
R Alan Wilson
PROVIDER: PRD000251 | Pride | 2010-06-03
REPOSITORIES: Pride
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Publications
Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts.
DeMarco Ricardo R Mathieson William W Manuel Sophia J SJ Dillon Gary P GP Curwen Rachel S RS Ashton Peter D PD Ivens Alasdair C AC Berriman Matthew M Verjovski-Almeida Sergio S Wilson R Alan RA
Genome research 20100706 8
Schistosoma mansoni is a well-adapted blood-dwelling parasitic helminth, persisting for decades in its human host despite being continually exposed to potential immune attack. Here, we describe in detail micro-exon genes (MEG) in S. mansoni, some present in multiple copies, which represent a novel molecular system for creating protein variation through the alternate splicing of short (< or =36 bp) symmetric exons organized in tandem. Analysis of three closely related copies of one MEG family all ...[more]
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