Dataset Information

Mouse APOE - Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge

ABSTRACT: mouse APOE-E3-437, Hippocampus mitochondrial fraction; Genotype: apoE3; Treatment: global ischemia

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hippocampus

SUBMITTER: Thierry Le Bihan

PROVIDER: PRD000363 | Pride | 2011-09-05

REPOSITORIES: Pride

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			Action	DRS
	PRIDE_Exp_Complete_Ac_15885.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_15885.pride.mztab.gz	Mztab
	PRIDE_Exp_Complete_Ac_15885.xml.gz	Xml
	PRIDE_Exp_Complete_Ac_15886.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_15886.pride.mztab.gz	Mztab

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Publications

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge.

James Rachel R Searcy James L JL Le Bihan Thierry T Martin Sarah F SF Gliddon Catherine M CM Povey Joanne J Deighton Ruth F RF Kerr Lorraine E LE McCulloch James J Horsburgh Karen K

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110831 1

Apolipoprotein E (APOE)-ɛ4 is associated with a deleterious outcome after ischemic brain injury, which may involve abnormal regulation of mitochondrial function. We have assessed the mitochondrial proteomic response of APOE-ɛ3 and APOE-ɛ4 transgenic mice to transient global ischemic injury in the hippocampus. A genotype-dependent increase in ApoE levels in mitochondria was observed after ischemia, with APOE-ɛ4 mice showing significantly greater increases than APOE-ɛ3 mice. Quantitative analysis ...[more]

PMID: 21878944

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