Proteomics

Dataset Information

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VISUALCTX - The synaptic proteome during development and plasticity of the mouse visual cortex


ABSTRACT: Not available

INSTRUMENT(S): instrument model, 4800 Proteomics Analyzer

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Pim van Nierop  

PROVIDER: PRD000397 | Pride | 2011-03-29

REPOSITORIES: Pride

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Publications

The synaptic proteome during development and plasticity of the mouse visual cortex.

Dahlhaus Martijn M   Li Ka Wan KW   van der Schors Roel C RC   Saiepour M Hadi MH   van Nierop Pim P   Heimel J Alexander JA   Hermans Josephine M JM   Loos Maarten M   Smit August B AB   Levelt Christiaan N CN  

Molecular & cellular proteomics : MCP 20110311 5


During brain development, the neocortex shows periods of enhanced plasticity, which enables the acquisition of knowledge and skills that we use and build on in adult life. Key to persistent modifications of neuronal connectivity and plasticity of the neocortex are molecular changes occurring at the synapse. Here we used isobaric tag for relative and absolute quantification to measure levels of 467 synaptic proteins in a well-established model of plasticity in the mouse visual cortex and the regu  ...[more]

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