Proteomics

Dataset Information

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TMT6-switch - Identification and quantification of S-nitrosylation by cysteine reactive tandem mass tag switch assay


ABSTRACT: HPAEC lysate treated with GSNO followed by TMT6-switch

INSTRUMENT(S): instrument model, LTQ Velos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Christopher Murray  

PROVIDER: PRD000411 | Pride | 2012-01-16

REPOSITORIES: Pride

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Identification and quantification of S-nitrosylation by cysteine reactive tandem mass tag switch assay.

Murray Christopher I CI   Uhrigshardt Helge H   O'Meally Robert N RN   Cole Robert N RN   Van Eyk Jennifer E JE  

Molecular & cellular proteomics : MCP 20111129 2


Redox-switches are critical cysteine thiols that are modified in response to changes in the cell's environment conferring a functional effect. S-nitrosylation (SNO) is emerging as an important modulator of these regulatory switches; however, much remains unknown about the nature of these specific cysteine residues and how oxidative signals are interpreted. Because of their labile nature, SNO-modifications are routinely detected using the biotin switch assay. Here, a new isotope coded cysteine th  ...[more]

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