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SAHA CCMS - SAHA Capture Compound--a novel tool for the profiling of histone deacetylases and the identification of additional vorinostat binders

ABSTRACT: SAHA CCMS in HepG2

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte

SUBMITTER: Jenny J. Fischer

PROVIDER: PRD000443 | Pride | 2011-10-19

REPOSITORIES: pride

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			Action	DRS
	PRIDE_Exp_Complete_Ac_17666.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_17666.pride.mztab.gz	Mztab
	PRIDE_Exp_Complete_Ac_17666.xml.gz	Xml
	PRIDE_Exp_Complete_Ac_17667.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_17667.pride.mztab.gz	Mztab

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Publications

SAHA Capture Compound--a novel tool for the profiling of histone deacetylases and the identification of additional vorinostat binders.

Fischer Jenny J JJ Michaelis Simon S Schrey Anna K AK Diehl Anne A Graebner Olivia Y OY Ungewiss Jan J Horzowski Sabine S Glinski Mirko M Kroll Friedrich F Dreger Mathias M Koester Hubert H

Proteomics 20110907 20

Suberoylanilide hydroxamic acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor. Inhibitors of HDACs are used in cancer therapy based on the role HDACs play in transcription by regulating chromatin compaction and non-histone proteins such as transcription factors. Profiling of HDAC expression is of interest in the functional proteomics analysis of cancer. Also, non-HDAC proteins may interact with HDAC inhibitor drugs and contribute to the drug mode of action. We here present a tool for t ...[more]

PMID: 21898820

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