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Mouse urine proteome in case of septic AKI

ABSTRACT: Mouse urine proteome in case of septic AKI

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Urine

SUBMITTER: Bert Maddens

PROVIDER: PRD000453 | Pride | 2013-07-08

REPOSITORIES: pride

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			Action	DRS
	PRIDE_Exp_Complete_Ac_17750.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_17750.pride.mztab.gz	Mztab
	PRIDE_Exp_Complete_Ac_17750.xml.gz	Xml

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Publications

Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury.

Maddens B B Ghesquière B B Vanholder R R Demon D D Vanmassenhove J J Gevaert K K Meyer E E

Molecular & cellular proteomics : MCP 20120110 6

Sepsis-induced acute kidney injury (AKI) is a frequent complication of critically ill patients and leads to high mortality rates. The specificity of currently available urinary biomarkers for AKI in the context of sepsis is questioned. This study aimed to discover urinary biomarkers for septic AKI by contemporary shotgun proteomics in a mouse model for sepsis and to validate these in individual urine samples of mice and human septic patients with and without AKI. At 48 h after uterine ligation a ...[more]

PMID: 22233884

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