Proteomics

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Proteomic analysis of the intestinal epithelial cell response to enteropathogenic Escherichia coli

ABSTRACT: Not available

INSTRUMENT(S): instrument model

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Attila Csordas  

PROVIDER: PRD000461 | Pride | 2012-07-26

REPOSITORIES: Pride

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Proteomic analysis of the intestinal epithelial cell response to enteropathogenic Escherichia coli.

Hardwidge Philip R PR   Rodriguez-Escudero Isabel I   Goode David D   Donohoe Sam S   Eng Jimmy J   Goodlett David R DR   Aebersold Reudi R   Finlay B Brett BB  

The Journal of biological chemistry 20040226 19

We present the first large scale proteomic analysis of a human cellular response to a pathogen. Enteropathogenic Escherichia coli (EPEC) is an enteric human pathogen responsible for much childhood morbidity and mortality worldwide. EPEC uses a type III secretion system (TTSS) to inject bacterial proteins into the cytosol of intestinal epithelial cells, resulting in diarrhea. We analyzed the host response to TTSS-delivered EPEC effector proteins by infecting polarized intestinal epithelial monola  ...[more]

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