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Platelet proteome - The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

ABSTRACT: iTRAQ quantification of human platelet proteins from four healthy donors measured on an Orbitrap XL.

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Platelet

SUBMITTER: Marc Vaudel

PROVIDER: PRD000665 | Pride | 2012-08-07

REPOSITORIES: Pride

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			Action	DRS
	PRIDE_Exp_Complete_Ac_22201.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_22201.pride.mztab.gz	Mztab
	PRIDE_Exp_Complete_Ac_22201.xml.gz	Xml
	PRIDE_Exp_Complete_Ac_22202.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_22202.pride.mztab.gz	Mztab

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The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways.

Burkhart Julia M JM Vaudel Marc M Gambaryan Stepan S Radau Sonja S Walter Ulrich U Martens Lennart L Geiger Jörg J Sickmann Albert A Zahedi René P RP

Blood 20120806 15

Antiplatelet treatment is of fundamental importance in combatting functions/dysfunction of platelets in the pathogenesis of cardiovascular and inflammatory diseases. Dysfunction of anucleate platelets is likely to be completely attributable to alterations in posttranslational modifications and protein expression. We therefore examined the proteome of platelets highly purified from fresh blood donations, using elaborate protocols to ensure negligible contamination by leukocytes, erythrocytes, and ...[more]

PMID: 22869793

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