Ontology highlight
ABSTRACT:
INSTRUMENT(S): instrument model
ORGANISM(S): Candida Glabrata (yeast) (torulopsis Glabrata)
SUBMITTER: DAVE THORNEYCROFT
PROVIDER: PRD000763 | Pride | 2007-05-04
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
PRIDE_Exp_Complete_Ac_1876.pride.mgf.gz | Mgf | |||
PRIDE_Exp_Complete_Ac_1876.xml.gz | Xml | |||
PRIDE_Exp_Complete_Ac_1877.pride.mgf.gz | Mgf | |||
PRIDE_Exp_Complete_Ac_1877.xml.gz | Xml |
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Stead David D Findon Helen H Yin Zhikang Z Walker Janet J Selway Laura L Cash Philip P Dujon Bernard A BA Hennequin Christophe C Brown Alistair J P AJ Haynes Ken K
Proteomics 20050501 7
Inactivation of the gene encoding the transcriptional activator Ace2 in the fungal pathogen Candida glabrata results in an almost 200-fold increase in virulence characterised by acute mortality and a massive over-stimulation of the pro-inflammatory arm of the innate immune system. In this study we have adopted a proteomics approach to identify cellular functions regulated by C. glabrata Ace2 that might contribute to this increase in virulence. A two-dimensional polyacrylamide gel electrophoresis ...[more]