Proteomics

Dataset Information

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Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene


ABSTRACT: Not available

INSTRUMENT(S): instrument model

ORGANISM(S): Candida Glabrata (yeast) (torulopsis Glabrata)

SUBMITTER: DAVE THORNEYCROFT  

PROVIDER: PRD000763 | Pride | 2007-05-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
PRIDE_Exp_Complete_Ac_1876.pride.mgf.gz Mgf
PRIDE_Exp_Complete_Ac_1876.xml.gz Xml
PRIDE_Exp_Complete_Ac_1877.pride.mgf.gz Mgf
PRIDE_Exp_Complete_Ac_1877.xml.gz Xml
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Publications

Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene.

Stead David D   Findon Helen H   Yin Zhikang Z   Walker Janet J   Selway Laura L   Cash Philip P   Dujon Bernard A BA   Hennequin Christophe C   Brown Alistair J P AJ   Haynes Ken K  

Proteomics 20050501 7


Inactivation of the gene encoding the transcriptional activator Ace2 in the fungal pathogen Candida glabrata results in an almost 200-fold increase in virulence characterised by acute mortality and a massive over-stimulation of the pro-inflammatory arm of the innate immune system. In this study we have adopted a proteomics approach to identify cellular functions regulated by C. glabrata Ace2 that might contribute to this increase in virulence. A two-dimensional polyacrylamide gel electrophoresis  ...[more]

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