Proteomics

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SILAC Osteoblast - Sulfated hyaluronan containing collagen matrices enhance cell-matrix-interaction, endocytosis, and osteogenic differentiation of human mesenchymal stromal cells


ABSTRACT: Differentiation of hMSCs into osteoblasts on aECMs.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Stefanie Kliemt  

PROVIDER: PXD000058 | Pride | 2012-12-19

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
366_6__H_Koll_1.raw Raw
366_6__H_Koll_2.raw Raw
366_6__H_Koll_3.raw Raw
366_6__H_Koll_4.raw Raw
366_6__H_Koll_5.raw Raw
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Publications

Sulfated hyaluronan containing collagen matrices enhance cell-matrix-interaction, endocytosis, and osteogenic differentiation of human mesenchymal stromal cells.

Kliemt Stefanie S   Lange Claudia C   Otto Wolfgang W   Hintze Vera V   Möller Stephanie S   von Bergen Martin M   Hempel Ute U   Kalkhof Stefan S  

Journal of proteome research 20121207 1


Inorganic-organic composite implant materials mimicking the environment of bone are promising applications to meet the increasing demands on biomaterials for bone regeneration caused by extended life spans and the concomitant increase of bone treatments. Besides collagen type I (Col-I) glycosaminoglycans (GAG), such as hyaluronan, are important components of the bone extracellular matrix (ECM). Sulfated GAGs are potential stimulators of bone anabolic activity, as they are involved in the recruit  ...[more]

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