Dataset Information
Melanoma NRAS - Cooperative induction of apoptosis in nras mutant melanoma by inhibition of mek and rock
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Whole Body
SUBMITTER: 
Teck Yew Low
LAB HEAD: Albert J.R. Heck
PROVIDER: PXD000528 | Pride | 2015-03-11
REPOSITORIES: pride
Dataset's files
Items per page: 1 - 5 of 174 |
Publications
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment cell & melanoma research 20150406 3
No effective targeted therapy is currently available for NRAS mutant melanoma. Experimental MEK inhibition is rather toxic and has only limited efficacy in clinical trials. At least in part, this is caused by the emergence of drug resistance, which is commonly seen for single agent treatment and shortens clinical responses. Therefore, there is a dire need to identify effective companion drug targets for NRAS mutant melanoma. Here, we show that at concentrations where single drugs had little effe ...[more]
