Proteomics

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Human pleural effusion LC-MSMS

ABSTRACT: We screened pleural effusion proteomes of mesothelioma and lung adenocarcinoma patients to identify novel soluble mesothelioma biomarkers. We performed quantitative mass spectrometry-(MS-) based proteomics using isobaric tags for relative and absolute quantification (iTRAQ) and used narrow range immobilized pH gradient/high resolution isoelectric focusing (IPG/HiRIEF; pH 4 to 4.25) prior to analysis by nano liquid chromatography-coupled MS/MS. Pleural effusions from patients with malignant mesothelioma (n=6), lung adenocarcinoma (n=6), or benign mesotheliosis (n=7) were analyzed, and more than 1,300 proteins were identified.

REANALYSED by: PAe005065

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Filip Mundt  

PROVIDER: PXD000531 | Pride | 2014-01-14

REPOSITORIES: Pride

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110302_FM_pool1_IPG_4_425_fr_01.raw Raw
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Publications

Proteome screening of pleural effusions identifies galectin 1 as a diagnostic biomarker and highlights several prognostic biomarkers for malignant mesothelioma.

Mundt Filip F   Johansson Henrik J HJ   Forshed Jenny J   Arslan Sertaç S   Metintas Muzaffer M   Dobra Katalin K   Lehtiö Janne J   Hjerpe Anders A  

Molecular & cellular proteomics : MCP 20131220 3

Malignant mesothelioma is an aggressive asbestos-induced cancer, and affected patients have a median survival of approximately one year after diagnosis. It is often difficult to reach a conclusive diagnosis, and ancillary measurements of soluble biomarkers could increase diagnostic accuracy. Unfortunately, few soluble mesothelioma biomarkers are suitable for clinical application. Here we screened the effusion proteomes of mesothelioma and lung adenocarcinoma patients to identify novel soluble me  ...[more]

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