Dataset Information

Leishmania donovani phosphoproteome during differentiation and as a response to environmental signals

ABSTRACT: Changes Leishmania donovani phosphoproteome during promastigote-to amastigote differentiation and as a response to environmental signals (pH and temperature) using TiO2 phosphopeptide enrichment and iTRAQ labeling. LC-MS/MS on QSTAR

INSTRUMENT(S): QSTAR

ORGANISM(S): Leishmania Donovani

SUBMITTER: Polina Tsigankov

LAB HEAD: Dan Zilberstein

PROVIDER: PXD000671 | Pride | 2014-04-24

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	EXP-101000795-early_differentiation.group	Other
	EXP-101000795.mzML	Mzml
	EXP-101000795Exclusion.mzML	Mzml
	EXP-101000795Q1high.mzML	Mzml
	EXP-101000795Q1low.mzML	Mzml

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Publications

Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends.

Tsigankov Polina P Gherardini Pier Federico PF Helmer-Citterich Manuela M Späth Gerald F GF Myler Peter J PJ Zilberstein Dan D

Molecular & cellular proteomics : MCP 20140416 7

Leishmania are obligatory intracellular parasitic protozoa that cause a wide range of diseases in humans, cycling between extracellular promastigotes in the mid-gut of sand flies and intracellular amastigotes in the phagolysosomes of mammalian macrophages. Although many of the molecular mechanisms of development inside macrophages remain a mystery, the development of a host-free system that simulates phagolysosome conditions (37 °C and pH 5.5) has provided new insights into these processes. The ...[more]

PMID: 24741111

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