Dataset Information

Metastatic pancreatic cancer signaling

ABSTRACT: Proteomic and signaling alterations among cells isolated from three sites of metastasis (liver, lung and peritoneum) from a single patient were studied using a SILAC-based quantitative proteomic strategy combined with a high resolution mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap XL, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Pancreatic Ductal Adenocarcinoma

SUBMITTER: Akhilesh Pandey

LAB HEAD: Min-Sik Kim

PROVIDER: PXD000750 | Pride | 2014-08-13

REPOSITORIES: Pride

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Publications

Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics.

Kim Min-Sik MS Zhong Yi Y Yachida Shinichi S Rajeshkumar N V NV Abel Melissa L ML Marimuthu Arivusudar A Mudgal Keshav K Hruban Ralph H RH Poling Justin S JS Tyner Jeffrey W JW Maitra Anirban A Iacobuzio-Donahue Christine A CA Pandey Akhilesh A

Molecular & cellular proteomics : MCP 20140603 11

Many patients with pancreatic cancer have metastases to distant organs at the time of initial presentation. Recent studies examining the evolution of pancreatic cancer at the genetic level have shown that clonal complexity of metastatic pancreatic cancer is already initiated within primary tumors, and organ-specific metastases are derived from different subclones. However, we do not yet understand to what extent the evolution of pancreatic cancer contributes to proteomic and signaling alteration ...[more]

PMID: 24895378

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			Action	DRS
	PancMet_IG_b1-24.msf	Msf
	PancMet_IG_b1-24.pep.xml	Pepxml
	PancMet_IG_b1.raw	Raw
	PancMet_IG_b10.raw	Raw
	PancMet_IG_b11.raw	Raw