Proteomics

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Colon cancer stem cell over-expressing ΔNp63α

ABSTRACT: p63, a member of p53 family, is transcribed in different variants, containing (TA) or lacking (ΔN) the N-terminal transactivation domain. Although the proteins of p53 family share high sequence and structural similarities, distinct functions for p63 are emerging. Here we provided a quantitative proteomic analysis by stable isotope dimethyl labeling of colon cancer stem cells over-expressing ΔNp63α in order to investigate the cellular pathways modulated by this p63 isoform.

INSTRUMENT(S): micrOTOF II

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Simona D'Aguanno  

LAB HEAD: Prof. Andrea Urbani

PROVIDER: PXD000769 | Pride | 2014-03-17

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
CRTL D2 DNp63 D0 Exp2 fract 1.dat-pride.pride.mgf.gz Mgf
CRTL D2 DNp63 D0 Exp2 fract 1.dat-pride.pride.mztab.gz Mztab
CRTL D2 DNp63 D0 Exp2 fract 10.dat-pride.pride.mgf.gz Mgf
CRTL D2 DNp63 D0 Exp2 fract 10.dat-pride.pride.mztab.gz Mztab
CRTL D2 DNp63 D0 Exp2 fract 12.dat-pride.pride.mgf.gz Mgf
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Publications

p63 is an important regulator of epithelial development expressed in different variants containing (TA) or lacking (ΔN) the N-terminal transactivation domain. The different isoforms regulate stem-cell renewal and differentiation as well as cell senescence. Several studies indicate that p63 isoforms also play a role in cancer development; however, very little is known about the role played by p63 in regulating the cancer stem phenotype. Here we investigate the cellular signals regulated by TAp63  ...[more]

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