Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Melanoma metastases: association between S100A13 expression and chemotherapy resistance

ABSTRACT: Here we have performed quantitative profiling of the proteome of lymph node metastasis from patients with melanoma with different response to chemotherapy.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Melanocyte, Lymph Node

DISEASE(S): Melanoma

SUBMITTER: Maria Pernemalm

LAB HEAD: Janne Lehtiö

PROVIDER: PXD000928 | Pride | 2014-04-25

REPOSITORIES: Pride

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	Maria_2010jun30_Melanoma-II_fr01.raw	Raw
	Maria_2010jun30_Melanoma-II_fr02.raw	Raw
	Maria_2010jun30_Melanoma-II_fr03.raw	Raw
	Maria_2010jun30_Melanoma-II_fr04.raw	Raw
	Maria_2010jun30_Melanoma-II_fr05.raw	Raw

Items per page:

1 - 5 of 150

Publications

Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance.

Azimi A A Pernemalm M M Frostvik Stolt M M Hansson J J Lehtiö J J Egyházi Brage S S Hertzman Johansson C C

British journal of cancer 20140410 10

<h4>Background</h4>Disseminated cutaneous malignant melanoma (CMM) is commonly unresponsive to standard chemotherapies, and there are as yet no predictive markers of therapy response.<h4>Methods</h4>In the present study we collected fresh-frozen pretreatment lymph-node metastasis samples (n=14) from melanoma patients with differential response to dacarbazine (DTIC) or temozolomide (TMZ) chemotherapy, to identify proteins with an impact on treatment response. We performed quantitative protein pro ...[more]

PMID: 24722184

Similar Datasets

Proteomics analysis of cystic fluid from human cystic papillary thyroid carcinoma

Project description:Here we have performed quantitative and qualitative profiling of the proteome of cystic fluid from human cystic papillary thyroid carcinoma with the aim to identify specific proteins and pathways involved in cystic fluid from human cystic papillary carcinoma, as well as possible diagnostic markers.

2015-05-20 | PXD000996 | Pride

Alterations in the membrane-associated proteome of alveolar macrophages in sarcoidosis

Project description:Here we have performed qualitative profiling of the membrane-associated proteome of alveolar macrophages in sarcoidosis patients and healthy individuals with the aim to identify specific proteins and pathways involved in sarcoidosis pathology.

2016-12-23 | PXD000752 | Pride

Plasma protein corona on superparamagnetic iron oxide nanoparticles (SPIONs)

Project description:We determined the composition of the plasma protein corona on silica-coated versus dextran-coated iron oxide nanoparticles using mass spectrometry-based proteomics approaches. Gene ontology (GO) enrichment analysis and Ingenuity Pathway Analysis (IPA) revealed distinct protein corona compositions for the two different SPIONs. Relaxivity of silica-coated SPIONs was modulated by the presence of a protein corona. Moreover, the viability of primary human monocyte-derived macrophages was influenced by the protein corona on silica-coated, but not dextran-coated SPIONs, and the protein corona promoted cellular uptake of silica-coated SPIONs, but did not affect internalization of dextran-coated SPIONs.

2015-10-12 | PXD000766 | Pride

Desorption electrospray ionisation mass spectrometry imaging of esophageal lymph mode metastases

Project description:Lymph node metastases (LNM) and primary tumour samples were analysed using desorption electrospray ionisation mass spectrometry imaging (DESI MSI). Current assessment of LNM depends on subjective histopathological assessment, whereas analysis by DESI MSI permits an entirely objective assessment. The mass spectral data revealed specific lipidomic patterns across samples, which were shown to correspond to the immunohistochemical image. Statistical prediction of LNM samples was performed using the esophageal adenocarcinoma samples with sensitivity and specificity of 89.5% and 100%, respectively.

2017-01-10 | MTBLS385 | MetaboLights

Spatial transcriptome analysis reveals the lymph node atlas of breast cancer metastases

Project description:To obtain more information about the lymph node metastasis of breast cancer cells, we performed spatial transcriptomics analysis of the positive lymph node (PL) with the 10× Genomics Visium platform, which allows characterization of the spatial topography of gene expression.

2024-11-17 | GSE189042 | GEO

Breast cancer metastases

Project description:We have analysed a unique tumour set of fourteen primary breast cancer tumours with matched synchronous axillary lymph node metastases and a set of nine primary tumours with, later developed, matched distant metastases spread to different sites in the body. The aim was to further understand the molecular changes during the spreading and identify differentially regulated proteins that may be novel biomarkers or treatment targets. We analysed the changes in glycoprotein expression since protein glycosylation is predominant in both membrane proteins and secreted proteins and these proteins are often important for cancer transformation. This may also allow affinity capture enabling selected reaction monitoring of these biomarkers in blood. Glycopeptide capture was used in this study to selectively isolate and quantify N-linked glycopeptides from tumours mixtures and the captured glycopeptides were subjected to label-free quantitative tandem mass spectrometry analysis. Differentially expressed proteins between primary tumours and matched lymph node metastasis and distant metastasis were identified. Two of the top hits, ATPIF1 and tubulin β-chain were validated to be differentially regulated with immunohistochemistry.

2022-02-28 | PXD001637 | Pride

Lymph Node Metastases in Colon Cancer are Polyclonal

Project description:Recent studies have highlighted the role of sub-clones in tumors. Lymph nodes are generally the first location of metastasis for most solid epithelial tumors including Colorectal cancer (CRC). We sought to understand the genetic origin of lymph node metastasis in CRC by evaluating the relationship between CRC tumor sub-clones and lymph nodes.

2017-11-22 | GSE107225 | GEO

Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer

Project description:Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-associated death rates. Triple negative breast cancers (TNBC) represent an important subtype that have an aggressive clinical phenotype, are associated with a higher likelihood of metastasis and are not responsive to current targeted therapies. miRNAs have emerged as an attractive candidate for molecular biomarkers and treatment targets in breast cancer, but their role in the progression of TNBC remains largely unexplored. This study has investigated miRNA expression profiles in 31 primary TNBC cases and in 13 lymph node metastases compared with 23 matched normal breast tissues to determine miRNAs associated with the initiation of this disease subtype and those associated with its metastasis. 71 miRNAs were differentially expressed in TNBC, the majority of which have previously been associated with breast cancer, including members of the miR-200 family and the miR-17-92 oncogenic cluster, suggesting that miRNAs involved in the initiation of TNBC are not subtype specific. However, the repertoire of miRNAs expressed in lymph node negative and lymph node positive TNBCs were largely distinct from one another. In particular, miRNA profiles associated with lymph node negative disease tended to be up-regulated, while those associated with lymph node positive disease were down-regulated and largely overlapped with the profiles of their matched lymph node metastases. miRNA expression profiles were examined in 31 primary TNBC cases and in 13 lymph node metastases compared with 23 matched normal breast tissues

2014-11-24 | E-GEOD-38167 | biostudies-arrayexpress

Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer

2014-11-24 | GSE38167 | GEO

Lymph Node Metastases in Colon Cancer are Polyclonal

Project description:Lymph Node Metastases in Colon Cancer are Polyclonal

| PRJNA419369 | ENA