Proteomics

Dataset Information

0

Human hippocampus LC-MSMS


ABSTRACT: Large-scale analysis of post-translational modification in the hippocampus of patients with Alzheimer's disease using pI shift and label free quantification without enrichment.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Taewook Kang  

LAB HEAD: Taewook Kang

PROVIDER: PXD000950 | Pride | 2022-02-22

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20111216_CON_PE_01.mzML Mzml
20111216_CON_PE_02.mzML Mzml
20111216_CON_PE_03.mzML Mzml
20111216_CON_PE_04.mzML Mzml
20111216_CON_PE_05.mzML Mzml
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Publications

Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment.

Kang Taewook T   Kim Jae Ho JH   Hong Ingie I   Park Nam Hyun NH   Heinsen Helmut H   Lee Joo-Yong JY   Ravid Rivka R   Ferrer Isidro I   Yoo Jong Shin JS   Kwon Kyung-Hoon KH   Park Young Mok YM  

Analytical and bioanalytical chemistry 20140815 22


Posttranslational modifications modulate protein function in cells. Global analysis of multiple posttranslational modifications can provide insight into physiology and disease, but presents formidable challenges. In the present study, we used a technique that does not require target enrichment to analyze alterations in the phosphorylation and ubiquitination of proteins from patients with Alzheimer's disease (AD). Guided by our previous findings, we applied three strategies to further our underst  ...[more]

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