Dataset Information

Glioma stem cells - Membrane-depolarizing channel blockers induce selective glioma cell death by impairing nutrient transport and unfolded protein/amino acid responses

ABSTRACT: Glioma stem cells treated with a drug (niguldipine) and the early response was monitored

INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Cell Culture

DISEASE(S): Glioblastoma

SUBMITTER: Gianluca Maddalo

LAB HEAD: Albert J.R. Heck

PROVIDER: PXD000970 | Pride | 2017-02-02

REPOSITORIES: pride

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			Action	DRS
	OR6_20140328_GM_KI_Glioma_Mix1_Fr1.raw	Raw
	OR6_20140328_GM_KI_Glioma_Mix1_Fr2.raw	Raw
	OR6_20140328_GM_KI_Glioma_Mix1_Fr3.raw	Raw
	OR6_20140328_GM_KI_Glioma_Mix1_Fr4.raw	Raw
	OR6_20140328_GM_KI_Glioma_Mix1_Fr5.raw	Raw

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Publications

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson Mia M Maddalo Gianluca G Sramkova Zuzana Z Mutlu Ercan E Wee Shimei S Sekyrova Petra P Schmidt Linnéa L Fritz Nicolas N Dehnisch Ivar I Kyriatzis Gregorios G Krafcikova Michaela M Carson Brittany B BB Feenstra Jennifer M JM Marinescu Voichita D VD Segerman Anna A Haraldsson Martin M Gustavsson Anna-Lena AL Hammarström Lars G J LG Jenmalm Jensen Annika A Uhrbom Lene L Altelaar A F Maarten AF Linnarsson Sten S Uhlén Per P Trantirek Lukas L Vincent C Theresa CT Nelander Sven S Enger Per Øyvind PØ Andäng Michael M

Cancer research 20170113 7

Glioma-initiating cells (GIC) are considered the underlying cause of recurrences of aggressive glioblastomas, replenishing the tumor population and undermining the efficacy of conventional chemotherapy. Here we report the discovery that inhibiting T-type voltage-gated Ca<sup>2+</sup> and K<sub>Ca</sub> channels can effectively induce selective cell death of GIC and increase host survival in an orthotopic mouse model of human glioma. At present, the precise cellular pathways affected by the drugs ...[more]

PMID: 28087597

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