Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human) Recombinant Hepatitis C Virus J6/jfh1-j6
TISSUE(S): Hepatocyte, Cell Culture
SUBMITTER: Ming-Jiun Yu
LAB HEAD: Ming-Jiun Yu
PROVIDER: PXD000988 | Pride | 2016-07-08
REPOSITORIES: Pride
Action | DRS | |||
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Sequest_Search_BioWorks_MultiConsensusReport.txt | Txt | |||
Unique_Sites_Summary_HCVPhosphoproteome.xlsx | Xlsx | |||
sample_01.RAW | Raw | |||
sample_01.mzXML | Mzxml | |||
sample_02.RAW | Raw |
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Chong Weng Man WM Hsu Shih-Chin SC Kao Wei-Ting WT Lo Chieh-Wen CW Lee Kuan-Ying KY Shao Jheng-Syuan JS Chen Yi-Hung YH Chang Justin J Chen Steve S-L SS Yu Ming-Jiun MJ
The Journal of biological chemistry 20151223 8
The non-structural protein 5A (NS5A) is a hepatitis C virus (HCV) protein indispensable for the viral life cycle. Many prior papers have pinpointed several serine residues in the low complexity sequence I region of NS5A responsible for NS5A phosphorylation; however, the functions of specific phosphorylation sites remained obscure. Using phosphoproteomics, we identified three phosphorylation sites (serines 222, 235, and 238) in the NS5A low complexity sequence I region. Reporter virus and replico ...[more]