Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: Alex von kriegsheim
LAB HEAD: Alex von Kriegsheim
PROVIDER: PXD001085 | Pride | 2016-03-30
REPOSITORIES: Pride
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Rodriguez Javier J Pilkington Ruth R Garcia Munoz Amaya A Nguyen Lan K LK Rauch Nora N Kennedy Susan S Monsefi Naser N Herrero Ana A Taylor Cormac T CT von Kriegsheim Alex A
Cell reports 20160310 11
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the asparagine hydroxylase FIH, which regulate the ...[more]