Proteomics

Dataset Information

0

Mycobacterium tuberculosis extracellular vesicle proteome


ABSTRACT: Tuberculosis is a common infectious disease mostly caused by Mycobacterium tuberculosis. M. tuberculosis have been shown to release extracellular vesicles (EVs) containing immunologically active molecules. However, only limited number of proteins has been identified in M. tuberculosis EVs. We present a comprehensive proteome of M. tuberculosis EVs to elucidate the pathogenesis of M. tuberculosis EVs and suggest several potential biomarker candidates.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mycobacterium Tuberculosis H37rv

TISSUE(S): Cell Culture

SUBMITTER: Jaewook Lee  

LAB HEAD: Yong Song Gho

PROVIDER: PXD001160 | Pride | 2015-07-30

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MtuberculosisEV.zip Other
MtuberculosisEV1.tandem.pep.xml Pepxml
MtuberculosisEV2.tandem.pep.xml Pepxml
MtuberculosisEV3.tandem.pep.xml Pepxml
MtuberculosisEV4.tandem.pep.xml Pepxml
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Publications

Proteomic analysis of extracellular vesicles derived from Mycobacterium tuberculosis.

Lee Jaewook J   Kim Si-Hyun SH   Choi Dong-Sic DS   Lee Jong Seok JS   Kim Dae-Kyum DK   Go Gyeongyun G   Park Seon-Min SM   Kim Si Hyun SH   Shin Jeong Hwan JH   Chang Chulhun L CL   Gho Yong Song YS  

Proteomics 20150819 19


The release of extracellular vesicles, also known as outer membrane vesicles, membrane vesicles, exosomes, and microvesicles, is an evolutionarily conserved phenomenon from bacteria to eukaryotes. It has been reported that Mycobacterium tuberculosis releases extracellular vesicles harboring immunologically active molecules, and these extracellular vesicles have been suggested to be applicable in vaccine development and biomarker discovery. However, the comprehensive proteomic analysis has not be  ...[more]

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