Proteomics

Dataset Information

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Hela-S3 ATPome - Proteome-Wide Discovery of Unknown ATP-Binding Proteins and Kinase Inhibitor Target Proteins Using an ATP Probe

ABSTRACT: ATP binding proteins (ATPome) dataset and ATPome-wide selectivity profiling of staurosporine and (s)-crizotinib

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jun Adachi  

LAB HEAD: Jun Adachi

PROVIDER: PXD001200 | Pride | 2014-10-20

REPOSITORIES: Pride

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Dataset's files

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Action DRS
1300809_AAS1set_01uM.raw Raw
1300809_AAS1set_0um01.raw Raw
1300809_AAS1set_0um02.raw Raw
1300809_AAS1set_1000uM.raw Raw
1300809_AAS1set_100uM.raw Raw
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Publications

Proteome-wide discovery of unknown ATP-binding proteins and kinase inhibitor target proteins using an ATP probe.

Adachi Jun J   Kishida Marina M   Watanabe Shio S   Hashimoto Yuuki Y   Fukamizu Kazuna K   Tomonaga Takeshi T  

Journal of proteome research 20140930 12

ATP-binding proteins, including protein kinases, play essential roles in many biological and pathological processes and thus these proteins are attractive as drug targets. Acyl-ATP probes have been developed as efficient probes for kinase enrichment, and these probes have also been used to enrich other ATP-binding proteins. However, a robust method to identify ATP-binding proteins with systematic elimination of nonspecific binding proteins has yet to be established. Here, we describe an ATP comp  ...[more]