Dataset Information

ITRAQ proteomics of non fibrotic carcinoma on Human Liver

ABSTRACT: We present a study of hepatocellular carcinoma developed on non-fibrotic liver (nfHCC) that combines complementary quantitative iTRAQ-based proteomics and phosphoproteomics approaches. Using both approaches, we analyzed a set of 24 samples (18 nfHCC vs 6 non-tumor liver tissue).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

DISEASE(S): Hepatocellular Carcinoma

SUBMITTER: Luc NEGRONI

LAB HEAD: Eric Chevet

PROVIDER: PXD001253 | Pride | 2014-09-18

REPOSITORIES: Pride

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Publications

Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers.

Negroni Luc L Taouji Said S Arma Daniela D Pallares-Lupon Nestor N Leong Kristen K Beausang Lee Anne LA Latterich Martin M Bossé Roger R Balabaud Charles C Schmitter Jean-Marie JM Bioulac-Sage Paulette P Zucman-Rossi Jessica J Rosenbaum Jean J Chevet Eric E

Molecular & cellular proteomics : MCP 20140915 12

Proteomics-based clinical studies represent promising resources for the discovery of novel biomarkers or for unraveling molecular mechanisms underlying particular diseases. Here, we present a discovery study of hepatocellular carcinoma developed on nonfibrotic liver (nfHCC) that combines complementary quantitative iTRAQ-based proteomics and phosphoproteomics approaches. Using both approaches, we compared a set of 24 samples (18 nfHCC versus six nontumor liver tissue). We identified 43 proteins ( ...[more]

PMID: 25225353

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			Action	DRS
	CHC120921_E1.RAW	Raw
	CHC120921_E1.msf	Msf
	CHC120921_E1.pep.xml	Pepxml
	CHC120921_E1.prot.xml	Xml
	CHC120921_E2.RAW	Raw