Proteomics

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Direct evidence of milk consumption from ancient human dental calculus, northern southwest Asia

ABSTRACT: This study investigated the consumption of milk products in the archaeological record, utilizing human dental calculus as a reservoir of dietary proteins from archaeological samples from across Eurasia. Protein extraction and generation of tryptic peptides from dental calculus was performed using a filter-aided sample preparation (FASP) protocol, modified for ancient samples, on 92 samples of archaeological dental calculus. Samples were extracted at three laboratories; the Functional Genomics Centre Zürich (FGCZ), the Centre for GeoGenetics at the National History Museum of Denmark, and BioArCh at the University of York. Sample extracts were sequenced (LC-MS/MS) using an LTQ-Orbitrap Velos (FGCZ), a Q-Exactive Hybrid Quadrupole Orbitrap and an LTQ-Orbitrap Elite (Central Proteomics Facility, Target Discovery Institute, Oxford).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Dental Plaque

SUBMITTER: Jessica Hendy  

LAB HEAD: Matthew Collins

PROVIDER: PXD001359 | Pride | 2015-02-26

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20130618_QE3_LC8_ChKe_COLLAB_ANCIENT_RISEneg_208.mgf Mgf
20130618_QE3_LC8_ChKe_COLLAB_ANCIENT_RISEneg_208.pride.mgf.gz Mgf
20130618_QE3_LC8_ChKe_COLLAB_ANCIENT_RISEneg_208.raw Raw
20131126_QE7_UPLC9_RJC_COLLAB_EE_268_01.raw Raw
20131126_QE7_UPLC9_RJC_COLLAB_EE_269_01.mgf Mgf
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Publications

Milk is a major food of global economic importance, and its consumption is regarded as a classic example of gene-culture evolution. Humans have exploited animal milk as a food resource for at least 8500 years, but the origins, spread, and scale of dairying remain poorly understood. Indirect lines of evidence, such as lipid isotopic ratios of pottery residues, faunal mortality profiles, and lactase persistence allele frequencies, provide a partial picture of this process; however, in order to und  ...[more]

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