Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ FT
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Bone Marrow, Bone Marrow Cell
DISEASE(S): Acute Leukemia
SUBMITTER: Thang Pham
LAB HEAD: Connie Ramona Jimenez
PROVIDER: PXD001476 | Pride | 2016-02-03
REPOSITORIES: pride
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Molecular & cellular proteomics : MCP 20160122 4
Expression of apoptosis-regulating proteins (B-cell CLL/lymphoma 2 - BCL-2, Myeloid Cell Leukemia 1 - MCL-1, BCL-2 like 1 - BCL-X and BCL-2-associated X protein - BAX) in acute myeloid leukemia (AML) blasts at diagnosis is associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while regaining high levels at relapse. Herein, we further explored this aspect of dynamic apoptosis regulation in AML. First, we showe ...[more]