Proteomics

Dataset Information

0

Elucidating the Linezolid response of Staphylococcus aureus USA300 (Hi3 quantification)


ABSTRACT: The translation inhibitor Linezolid is an important antibiotic of last resort against multiresistant gram-positive pathogens including MRSA. Linezolid is reported to specifically inhibit extracellular virulence factors, but the molecular cause is unknown. To elucidate the physiological response of S. aureus to Linezolid in general and the possible inhibition of virulence factors specifically we performed a holistic study. We added Linezolid to logarithmically growing S. aureus cells and analysed the Linezolid stress response with transcriptomics, quantitative proteomics and microscopy experiments.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Florian Bonn  

LAB HEAD: Dörte Becher

PROVIDER: PXD001659 | Pride | 2016-03-18

REPOSITORIES: Pride

altmetric image

Publications

Global analysis of the impact of linezolid onto virulence factor production in S. aureus USA300.

Bonn Florian F   Pané-Farré Jan J   Schlüter Rabea R   Schaffer Marc M   Fuchs Stephan S   Bernhardt Jörg J   Riedel Katharina K   Otto Andreas A   Völker Uwe U   van Dijl Jan Maarten JM   Hecker Michael M   Mäder Ulrike U   Becher Dörte D  

International journal of medical microbiology : IJMM 20160217 3


The translation inhibitor linezolid is an antibiotic of last resort against Gram-positive pathogens including methicillin resistant strains of the nosocomial pathogen Staphylococcus aureus. Linezolid is reported to inhibit production of extracellular virulence factors, but the molecular cause is unknown. To elucidate the physiological response of S. aureus to linezolid in general and the inhibition of virulence factor synthesis in particular a holistic study was performed. Linezolid was added to  ...[more]

Similar Datasets

2016-03-18 | PXD001622 | Pride
2018-09-13 | PXD010498 | Pride
2014-06-05 | E-GEOD-38531 | biostudies-arrayexpress
2014-06-05 | GSE38531 | GEO
2016-02-22 | GSE65209 | GEO
2016-02-22 | E-GEOD-65209 | biostudies-arrayexpress
2023-03-11 | PXD030971 | Pride
2022-02-24 | PXD025586 | Pride
2021-09-09 | PXD017973 | Pride
2013-02-12 | E-GEOD-44210 | biostudies-arrayexpress