Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis, impact
ORGANISM(S): Gallus Gallus (chicken)
TISSUE(S): Embryo, Egg, Early Embryonic Cell
DISEASE(S): Retinitis
SUBMITTER: Francois Delalande
LAB HEAD: Alain Van Dorsselaer
PROVIDER: PXD001715 | Pride | 2016-06-15
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
F167664.dat | Other | |||
F167664.dat-pride.pride.mgf.gz | Mgf | |||
F167664.dat-pride.pride.mztab.gz | Mztab | |||
F167664.dat-pride.xml.gz | Xml | |||
F167666.dat | Other |
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Cell 20150501 4
Rod-derived cone viability factor (RdCVF) is an inactive thioredoxin secreted by rod photoreceptors that protects cones from degeneration. Because the secondary loss of cones in retinitis pigmentosa (RP) leads to blindness, the administration of RdCVF is a promising therapy for this untreatable neurodegenerative disease. Here, we investigated the mechanism underlying the protective role of RdCVF in RP. We show that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed ...[more]