Dataset Information

Branch retinal vein occlusion in a porcine model

ABSTRACT: Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the disease remain largely unelucidated. To bring new insights into pathological processes and elucidate potential therapeutic targets, large-scale retinal protein changes following BRVO were studied by combining a porcine model of experimental BRVO with proteomic analysis by label-free liquid chromatography mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Retina

DISEASE(S): Eye Disease

SUBMITTER: Allan Stensballe

LAB HEAD: Allan Stensballe

PROVIDER: PXD001800 | Pride | 2015-07-30

REPOSITORIES: Pride

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Proteins involved in focal adhesion signaling pathways are differentially regulated in experimental branch retinal vein occlusion.

Cehofski Lasse Jørgensen LJ Kruse Anders A Kjærgaard Benedict B Stensballe Allan A Honoré Bent B Vorum Henrik H

Experimental eye research 20150615

Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the condition remain largely unelucidated. To bring new insights into pathological processes and identify potential therapeutic targets, large-scale retinal protein changes following BRVO were studied by combining a porcine model of experimental BRVO with proteomic analysis by label-free liquid chromatography mass spectrometry. Among a total set of 1974 proteins, 52 significantly upreg ...[more]

PMID: 26086079

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