Proteomics

Dataset Information

0

Heart Mitochondrial Proteome - The Failing Heart Relies on Ketone Bodies as a Fuel


ABSTRACT: Isolation of Heart Mitochondria of defined stages of pressure overload-induced heart failure in mice

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Marcus Krueger  

LAB HEAD: Krueger

PROVIDER: PXD001820 | Pride | 2016-05-09

REPOSITORIES: Pride

Dataset's files

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Publications


<h4>Background</h4>Significant evidence indicates that the failing heart is energy starved. During the development of heart failure, the capacity of the heart to utilize fatty acids, the chief fuel, is diminished. Identification of alternate pathways for myocardial fuel oxidation could unveil novel strategies to treat heart failure.<h4>Methods and results</h4>Quantitative mitochondrial proteomics was used to identify energy metabolic derangements that occur during the development of cardiac hype  ...[more]

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