Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Marcus Krueger
LAB HEAD: Krueger
PROVIDER: PXD001820 | Pride | 2016-05-09
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 234 |
Aubert Gregory G Martin Ola J OJ Horton Julie L JL Lai Ling L Vega Rick B RB Leone Teresa C TC Koves Timothy T Gardell Stephen J SJ Krüger Marcus M Hoppel Charles L CL Lewandowski E Douglas ED Crawford Peter A PA Muoio Deborah M DM Kelly Daniel P DP
Circulation 20160127 8
<h4>Background</h4>Significant evidence indicates that the failing heart is energy starved. During the development of heart failure, the capacity of the heart to utilize fatty acids, the chief fuel, is diminished. Identification of alternate pathways for myocardial fuel oxidation could unveil novel strategies to treat heart failure.<h4>Methods and results</h4>Quantitative mitochondrial proteomics was used to identify energy metabolic derangements that occur during the development of cardiac hype ...[more]