Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE64992PRJNA272676PRJNA272677PRJNA272675PRJNA272673
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Schizosaccharomyces Pombe
SUBMITTER: Tamas Fischer
LAB HEAD: Dr. Tamas Fischer
PROVIDER: PXD001908 | Pride | 2015-04-22
REPOSITORIES: Pride
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Nature communications 20150520
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the exosome is not fully understood. Here we report that the MTREC complex, which has recently been shown to promote degradation of meiotic mRNAs and regulatory ncRNAs, is also the major nuclear exosome targeting complex for CUTs and unspliced pre-mRNAs in Schizosaccharomyces pombe. The MTREC complex specifically binds to CUTs, meiotic mRNAs and uns ...[more]