Proteomics

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Multi-omics approach to identify age-related changes in mesenchymal stem cells

ABSTRACT: Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstrated to possess an age-related loss of cellular functions including differentiation potential and proliferation capacity; with implications for stem cell therapies in older patients. Furthermore the reduction in differentiation potential could contribute to ageing and age-related disease. Biological aging is coupled with a progressive reduction in the regulation of cellular, tissue and organ interaction, resulting in senescence. The purpose of this study was to investigate the epigenetic, RNA and protein changes in ageing MSCs in order to understand the age-related functional and biological changes required for their applications in regenerative medicine.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Cell Culture

SUBMITTER: Mandy Peffers  

LAB HEAD: Mandy J Peffers

PROVIDER: PXD001952 | Pride | 2016-02-16

REPOSITORIES: Pride

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Action DRS
human_msc_young_and_old.mgf Mgf
human_msc_young_and_old.pride.mgf.gz Mgf
msc_young_and_old_unihuman_reviewed.mzid.gz Mzid
msc_young_and_old_unihuman_reviewed.pride.mztab.gz Mztab
old1_2h.raw Raw
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Age-related changes in mesenchymal stem cells identified using a multi-omics approach.

Peffers M J MJ   Collins J J   Fang Y Y   Goljanek-Whysall K K   Rushton M M   Loughlin J J   Proctor C C   Clegg P D PD  

European cells & materials 20160208

Mesenchymal stem cells (MSC) are capable of multipotent differentiation into connective tissues and as such are an attractive source for autologous cell-based treatments for many clinical diseases and injuries. Ageing is associated with various altered cellular phenotypes coupled with a variety of transcriptional, epigenetic and translational changes. Furthermore, the regeneration potential of MSCs is reduced with increasing age and is correlated with changes in cellular functions. This study us  ...[more]

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