Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Escherichia Coli
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Mixed Disorder As Reaction To Stress
SUBMITTER: Alexander Schmidt
LAB HEAD: Alexander Schmidt
PROVIDER: PXD001968 | Pride | 2016-09-27
REPOSITORIES: Pride
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Radzikowski Jakub Leszek JL Vedelaar Silke S Siegel David D Ortega Álvaro Dario ÁD Schmidt Alexander A Heinemann Matthias M
Molecular systems biology 20160921 9
While persisters are a health threat due to their transient antibiotic tolerance, little is known about their phenotype and what actually causes persistence. Using a new method for persister generation and high-throughput methods, we comprehensively mapped the molecular phenotype of Escherichia coli during the entry and in the state of persistence in nutrient-rich conditions. The persister proteome is characterized by σ(S)-mediated stress response and a shift to catabolism, a proteome that starv ...[more]