Proteomics

Dataset Information

0

Giardia duodenalis Encystation Strain Variation


ABSTRACT: Giardia duodenalis is a protozoan parasite responsible for gastroenteritis in vertebrates, including humans. The prevalence of G. duodenalis is partly owed to its direct and simple life cycle, as well as the formation of the environmentally resistant and infective cysts. Several proteomic and transcriptomic studies have previously analysed global changes during the encystation process using the well-characterised laboratory isolate and genome strain, WBC6. To expand current comparative analyses, this study presents the first quantitative global study of encystation using pathogenically relevant and alternative assemblage A strains: the human-derived BRIS/82/HEPU/106 and avian-derived BRIS/95/HEPU/2041. We have utilised tandem MS/MS with a label-free quantitative approach to compare cysts and trophozoite life stages between strains for variation, as well as confirm universal encystation markers of Assemblage A.

INSTRUMENT(S): LTQ Velos

ORGANISM(S): Giardia Intestinalis Assemblage A

SUBMITTER: Samantha Emery  

LAB HEAD: Paul A Haynes

PROVIDER: PXD002002 | Pride | 2015-06-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
106CystsR1F1.raw Raw
106CystsR1F2.raw Raw
106CystsR1F3.raw Raw
106CystsR1F4.raw Raw
106CystsR1Merged.xml Xml
Items per page:
1 - 5 of 60
altmetric image

Publications

The generation gap: Proteome changes and strain variation during encystation in Giardia duodenalis.

Emery Samantha J SJ   Pascovi Dana D   Lacey Ernest E   Haynes Paul A PA  

Molecular and biochemical parasitology 20150501 1


The prevalence of Giardia duodenalis in humans is partly owed to its direct and simple life cycle, as well as the formation of the environmentally resistant and infective cysts. Proteomic and transcriptomic studies have previously analysed the encystation process using the well-characterised laboratory genomic strain, WB C6. This study presents the first quantitative study of encystation using pathogenically relevant and alternative assemblage A strains: the human-derived BRIS/82/HEPU/106 (H-106  ...[more]

Similar Datasets

2015-02-26 | PXD001272 | Pride
2023-02-08 | PXD016863 | Pride
2011-10-29 | GSE33312 | GEO
2011-10-28 | E-GEOD-33312 | biostudies-arrayexpress
2022-01-10 | GSE141795 | GEO
2021-07-05 | PXD025785 | Pride
2021-07-11 | PXD024428 | Pride
2021-07-10 | PXD024944 | Pride
2015-09-29 | PRD000728 | Pride
| PRJNA594734 | ENA