Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Keratinocyte, Skin, Fibroblast
DISEASE(S): Epidermolysis Bullosa
SUBMITTER: Joern Dengjel
LAB HEAD: Joern Dengjel
PROVIDER: PXD002134 | Pride | 2015-10-02
REPOSITORIES: pride
Items per page: 5 1 - 5 of 111 |
Nyström Alexander A Thriene Kerstin K Mittapalli Venugopal V Kern Johannes S JS Kiritsi Dimitra D Dengjel Jörn J Bruckner-Tuderman Leena L
EMBO molecular medicine 20150901 9
Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)-a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive. Here, we report an alternative evidence-based approach to ameliorate fibrosis and relieve symptoms in RDEB. Based on the findings that TGF-β activity is elevated in injured RDEB skin, we ...[more]