Proteomics

Dataset Information

0

Fly Stress - Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

ABSTRACT: Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. While ageing and fasting alter many redox processes, the role of cysteine residues is uncertain. To address this we used a redox proteomic technique, Oxidative Isotope Coded Affinity TAgs (OxICAT), to assess cysteine residue redox changes in Drosophila melanogaster during ageing and fasting. This approach enabled us to simultaneously identify and quantify the redox state of several hundred cysteine residues in vivo.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Whole Body

SUBMITTER: Andrew James  

LAB HEAD: Michael Patrick Murphy

PROVIDER: PXD002195 | Pride | 2018-10-24

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
CatalaseOverexControl.zip Other
CatalaseOverexH2O2.zip Other
CatalaseOverexPQ.zip Other
CatalaseOverexStarve.zip Other
SupplementalTable1.zip Other
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Publications

Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage.

Kelley Mark R MR   Kelley Mark R MR   Fehrenbacher Jill C JC  

Neural regeneration research 20170101 1